Food, polyphenols and neuroprotection

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Food, polyphenols and neuroprotection

Neuron loss and neurodegeneration are the common denominators of what are known as neurodegenerative diseases. Although the clinical manifestations of some neurodegenerative diseases are mainly associated with ageing, it is believed that onset of disease and neuronal death occurs progressively through life, well before the first symptoms appear. So, one of the main dilemmas regarding neurodegen...

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Wine Polyphenols: Potential Agents in Neuroprotection

There are numerous studies indicating that a moderate consumption of red wine provides certain health benefits, such as the protection against neurodegenerative diseases. This protective effect is most likely due to the presence of phenolic compounds in wine. Wine polyphenolic compounds are well known for the antioxidant properties. Oxidative stress is involved in many forms of cellular and mol...

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Polyphenols: food sources and bioavailability.

Polyphenols are abundant micronutrients in our diet, and evidence for their role in the prevention of degenerative diseases such as cancer and cardiovascular diseases is emerging. The health effects of polyphenols depend on the amount consumed and on their bioavailability. In this article, the nature and contents of the various polyphenols present in food sources and the influence of agricultur...

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Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia.

Brain ischemia induces neuronal loss which is caused in part by excitotoxicity and free radical formation. Here, we report that mangiferin and morin, two antioxidant polyphenols, are neuroprotective in both in vitro and in vivo models of ischemia. Cell death caused by glutamate in neuronal cultures was decreased in the presence of submicromolar concentrations of mangiferin or morin which in tur...

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Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear f...

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ژورنال

عنوان ژورنال: Neural Regeneration Research

سال: 2017

ISSN: 1673-5374

DOI: 10.4103/1673-5374.205096